Colorectal Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Colorectal Cancer, including details on symptoms, genetics, screening, treatment, information.

Volume 5 (2008), Issue 4 (April)

1. Adiponectin and colorectal adenomas: Self Defense Forces Health Study.
   Cancer Sci, 99(4): 781-6. [Abstract] [Full-text]
2. Clinical features and mismatch repair genes analyses of Chinese suspected hereditary non-polyposis colorectal cancer: a cost-effective screening strategy proposal.
   Cancer Sci, 99(4): 770-80. [Abstract] [Full-text]
3. Orthotopic implantation mouse model and cDNA microarray analysis indicates several genes potentially involved in lymph node metastasis of colorectal cancer.
   Cancer Sci, 99(4): 711-9. [Abstract] [Full-text]
4. Susceptibility of Snark-deficient mice to azoxymethane-induced colorectal tumorigenesis and the formation of aberrant crypt foci.
   Cancer Sci, 99(4): 677-82. [Abstract] [Full-text]
5. Wnt signaling inside the nucleus.
   Cancer Sci, 99(4): 631-7. [Abstract] [Full-text]
6. Ageing and hepatic steatosis exacerbate ischemia/reperfusion-accelerated outgrowth of colorectal micrometastases.
   Ann Surg Oncol, 15(5): 1392-8. [Abstract] [Full-text]
7. Two subtypes of mucinous adenocarcinoma of the colorectum: clinicopathological and genetic features.
   Ann Surg Oncol, 15(5): 1429-39. [Abstract] [Full-text]
8. High-resolution anoscopy in the diagnosis of anal cancer precursor lesions in renal graft recipients.
   Ann Surg Oncol, 15(5): 1470-5. [Abstract] [Full-text]
9. Clinical significance of BMP7 in human colorectal cancer.
   Ann Surg Oncol, 15(5): 1530-7. [Abstract] [Full-text]
10. Laparoscopic bowel resection in the setting of metastatic colorectal cancer.
    Ann Surg Oncol, 15(5): 1424-8. [Abstract] [Full-text]
11. Phase I trial of pegylated liposomal doxorubicin with hyperthermic intraperitoneal chemotherapy in patients undergoing cytoreduction for advanced intra-abdominal malignancy.
    Ann Surg Oncol, 15(5): 1407-13. [Abstract] [Full-text]
12. The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner.
    Cancer Res, 68(7): 2312-20. [Abstract] [Full-text]
13. Origins and prevalence of the American Founder Mutation of MSH2.
    Cancer Res, 68(7): 2145-53. [Abstract] [Full-text]
14. BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-kappaB activity.
    Carcinogenesis, 29(4): 849-57. [Abstract] [Full-text]
15. Dietary fish oil and pectin enhance colonocyte apoptosis in part through suppression of PPARdelta/PGE2 and elevation of PGE3.
    Carcinogenesis, 29(4): 790-6. [Abstract] [Full-text]
16. Is thoracoscopic surgery justified to treat pulmonary metastasis from colorectal cancer?
    Interact Cardiovasc Thorac Surg, 7(2): 212-6; discussion 216-7. [Abstract] [Full-text]
17. Distress among inflammatory bowel disease patients at high risk for colorectal cancer: a preliminary investigation of the effects of family history of cancer, disease duration, and perceived social support.
    Psychooncology, 17(4): 354-62. [Abstract] [Full-text]
18. Tenascin-W, a new marker of cancer stroma, is elevated in sera of colon and breast cancer patients.
    Int J Cancer, 122(11): 2454-61. [Abstract] [Full-text]
19. Integrin alpha v beta 6 mediates the potential for colon cancer cells to colonize in and metastasize to the liver.
    Cancer Sci, 99(5): 879-87. [Abstract] [Full-text]
20. Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.
    Int J Cancer, 122(11): 2462-70. [Abstract] [Full-text]
21. Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis.
    Int J Cancer, 122(11): 2429-36. [Abstract] [Full-text]
22. Difference in characteristics of APC mutations between colonic and extracolonic tumors of FAP patients: variations with phenotype.
    Int J Cancer, 122(11): 2491-7. [Abstract] [Full-text]
23. The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer in a case control study and meta-analysis.
    Int J Cancer, 122(11): 2573-80. [Abstract] [Full-text]
24. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer.
    Oncogene, 27(15): 2128-36. [Abstract] [Full-text]
25. Outcomes of immediate vertical rectus abdominis myocutaneous flap reconstruction for irradiated abdominoperineal resection defects.
    J Am Coll Surg, 206(4): 694-703. [Abstract] [Full-text]
26. Is there still a role for double-contrast barium enema examination?
    Clin Gastroenterol Hepatol, 6(4): 389-92. [Abstract] [Full-text]
27. Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer.
    J Surg Res, 146(1): 16-23. [Abstract] [Full-text]
28. Prognostic values of matrix metalloproteinase family expression in human colorectal carcinoma.
    J Surg Res, 146(1): 32-42. [Abstract] [Full-text]
29. Chemoprevention of colorectal neoplasia: the potential for personalized medicine.
    Gastroenterology, 134(4): 1224-37. [Abstract] [Full-text]
30. The specific immune response to tumor antigen CP1 and its correlation with improved survival in colon cancer patients.
    Gastroenterology, 134(4): 998-1006. [Abstract] [Full-text]
31. Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers.
    Gastroenterology, 134(4): 988-97. [Abstract] [Full-text]
32. Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy.
    Nat Med, 14(4): 454-8. [Abstract] [Full-text]
33. Diagnosis and management of peritoneal carcinomatosis arising from adenocarcinoma of the colon and rectum.
    Semin Oncol, 35(2): 183-91. [Abstract] [Full-text]
34. Bone morphogenic protein 3 inactivation is an early and frequent event in colorectal cancer development.
    Genes Chromosomes Cancer, 47(6): 449-60. [Abstract] [Full-text]
35. Café-au-lait macules and pediatric malignancy caused by biallelic mutations in the DNA mismatch repair (MMR) gene PMS2.
    Pediatr Blood Cancer, 50(6): 1268-70. [Abstract] [Full-text]
36. Bevacizumab, capecitabine, and oxaliplatin as neoadjuvant therapy for patients with potentially curable metastatic colorectal cancer.
    J Clin Oncol, 26(11): 1830-5. [Abstract] [Full-text]
37. p53 regulates FAK expression in human tumor cells.
    Mol Carcinog, 47(5): 373-82. [Abstract] [Full-text]
38. Chemoprevention of familial adenomatous polyposis in Apc(Min/+) mice by phenethyl isothiocyanate (PEITC).
    Mol Carcinog, 47(5): 321-5. [Abstract] [Full-text]
39. Human APC sequesters beta-catenin even in the absence of GSK-3beta in a Drosophila model.
    Oncogene, 27(17): 2488-93. [Abstract] [Full-text]
40. Progress and challenges in the adjuvant treatment of stage II and III colon cancers.
    Expert Rev Anticancer Ther, 8(4): 595-604. [Abstract] [Full-text]
41. Emerging role of intensity-modulated radiation therapy in anorectal cancer.
    Expert Rev Anticancer Ther, 8(4): 585-93. [Abstract] [Full-text]
42. Lynch syndrome in colorectal cancer patients.
    Expert Rev Anticancer Ther, 8(4): 573-83. [Abstract] [Full-text]
43. Immune cells in colorectal cancer: prognostic relevance and therapeutic strategies.
    Expert Rev Anticancer Ther, 8(4): 561-72. [Abstract] [Full-text]
44. Redefining adjuvant chemotherapy in patients with stage III colon cancer: X-ACT trial.
    Expert Rev Anticancer Ther, 8(4): 547-51. [Abstract] [Full-text]
45. Hypermethylated MAL gene - a silent marker of early colon tumorigenesis.
    J Transl Med, 6: 13. [Abstract] [Full-text]
46. Colon and rectum cancer in Thailand: an overview.
    Jpn J Clin Oncol, 38(4): 237-43. [Abstract] [Full-text]
47. In vivo real-time confocal laser scanning endomicroscopic colonoscopy for the detection and characterization of colorectal neoplasia.
    Br J Surg, 95(5): 636-45. [Abstract] [Full-text]
48. A case of lateral pelvic lymph node recurrence after TME for submucosal rectal carcinoma successfully treated by lymph node dissection with en bloc resection of the internal iliac vessels.
    Jpn J Clin Oncol, 38(4): 305-7. [Abstract] [Full-text]
49. Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice.
    Gut, 57(5): 613-22. [Abstract] [Full-text]
50. Guidelines for the clinical management of familial adenomatous polyposis (FAP).
    Gut, 57(5): 704-13. [Abstract] [Full-text]
51. Large genomic deletions of SMAD4, BMPR1A and PTEN in juvenile polyposis.
    Gut, 57(5): 623-7. [Abstract] [Full-text]
52. Efficacy of direct electrical current therapy and laser-induced interstitial thermotherapy in local treatment of hepatic colorectal metastases: an experimental model in the rat.
    J Surg Res, 146(2): 230-40. [Abstract] [Full-text]
53. Quantitative and qualitative characterization of plasma DNA identifies primary and recurrent colorectal cancer.
    Cancer Lett, 263(2): 170-81. [Abstract] [Full-text]
54. Effects of adjuvant chemotherapy on bone marrow mesenchymal stem cells of colorectal cancer patients.
    Cancer Lett, 263(2): 197-203. [Abstract] [Full-text]
55. Molecular signature detection of circulating tumor cells using a panel of selected genes.
    Cancer Lett, 263(2): 267-79. [Abstract] [Full-text]
56. Not all acute lower back pain is benign--paravertebral abscess and colonic cancer.
    Am J Emerg Med, 26(4): 513.e3-4. [Abstract] [Full-text]
57. Anti-tumor activity of ESX1 on cancer cells harboring oncogenic K-ras mutation.
    Biochem Biophys Res Commun, 370(1): 189-94. [Abstract] [Full-text]
58. PPARgamma ligands suppress the feedback loop between E2F2 and cyclin-E1.
    Biochem Biophys Res Commun, 370(1): 145-8. [Abstract] [Full-text]
59. Computed tomographic colonography to screen for colorectal cancer, extracolonic cancer, and aortic aneurysm: model simulation with cost-effectiveness analysis.
    Arch Intern Med, 168(7): 696-705. [Abstract] [Full-text]
60. Evaluation of a radiographer-provided barium enema service.
    Colorectal Dis, 10(4): 394-6. [Abstract] [Full-text]
61. Who should be followed up after transanal endoscopic resection of rectal tumours?
    Colorectal Dis, 10(4): 330-5. [Abstract] [Full-text]
62. Transanal endoscopic microsurgery in early rectal cancer: time for a trial?
    Colorectal Dis, 10(4): 314-27; discussion 327-9. [Abstract] [Full-text]
63. The predictive value of p53 and p33(ING1b) in patients with Dukes'C colorectal cancer.
    Colorectal Dis, 10(4): 344-51. [Abstract] [Full-text]
64. Does the laparoscopic colorectal surgery learning curve adversely affect the results of colorectal cancer resection? A 3-year prospective study in a district general hospital.
    Colorectal Dis, 10(4): 363-9. [Abstract] [Full-text]
65. Palliative surgery for rectal cancer in a national cohort.
    Colorectal Dis, 10(4): 336-43. [Abstract] [Full-text]
66. How do we manage early rectal cancer? A national questionnaire survey among members of the ACPGBI after the preliminary results of the MRC CR07/NCIC CO16 randomized trial.
    Colorectal Dis, 10(4): 357-62. [Abstract] [Full-text]
67. Internet information on colorectal cancer: commercialization and lack of quality control.
    Colorectal Dis, 10(4): 352-6. [Abstract] [Full-text]
68. Colorectal tubulovillous adenomas identified on fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography scans.
    Colorectal Dis, 10(4): 386-9. [Abstract] [Full-text]
69. Dissection of spontaneous cytotoxicity by human intestinal intraepithelial lymphocytes: MIC on colon cancer triggers NKG2D-mediated lysis through Fas ligand.
    Immunology, 124(1): 33-41. [Abstract] [Full-text]
70. The proapoptotic effects of sulindac, sulindac sulfone and indomethacin are mediated by nucleolar translocation of the RelA(p65) subunit of NF-kappaB.
    Oncogene, 27(18): 2648-55. [Abstract] [Full-text]
71. Validation of patient's self-reported social functioning as an independent prognostic factor for survival in metastatic colorectal cancer patients: results of an international study by the Chronotherapy Group of the European Organisation for Research and Treatment of Cancer.
    J Clin Oncol, 26(12): 2020-6. [Abstract] [Full-text]
72. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study.
    J Clin Oncol, 26(12): 2013-9. [Abstract] [Full-text]
73. Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer.
    J Clin Oncol, 26(12): 2006-12. [Abstract] [Full-text]
74. Systematic survey of therapeutic trials for metastatic colorectal cancer: room for improvement in the critical pathway.
    J Clin Oncol, 26(12): 2000-5. [Abstract] [Full-text]
75. Treatment of advanced or recurrent colorectal cancer with irinotecan in Japan and elsewhere.
    Expert Opin Pharmacother, 9(7): 1223-8. [Abstract] [Full-text]
76. Does surgeon fatigue influence outcomes after anterior resection for rectal cancer?
    Am J Surg, 195(5): 684-7; discussion 687-8. [Abstract] [Full-text]
77. Clinical utility of type 1 growth factor receptor expression in colon cancer.
    Am J Surg, 195(5): 604-10. [Abstract] [Full-text]
78. Impact of short-course radiotherapy and low anterior resection on quality of life and bowel function in primary rectal cancer.
    Am J Surg, 195(5): 611-5; discussion 615. [Abstract] [Full-text]
79. Cellular expression patterns of genes upregulated in murine and human colonic neoplasms.
    J Histochem Cytochem, 56(5): 433-41. [Abstract] [Full-text]
80. Reduction of Calponin h1 expression in human colon cancer blood vessels.
    Eur J Surg Oncol, 34(5): 531-7. [Abstract] [Full-text]
81. Effect of modified Davidson's fixative on examined number of lymph nodes and TNM-stage in colon carcinoma.
    Eur J Surg Oncol, 34(5): 525-30. [Abstract] [Full-text]
82. The Oncosurge strategy for the management of colorectal liver metastases - an external validation study.
    Eur J Surg Oncol, 34(5): 538-40. [Abstract] [Full-text]
83. Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial.
    JAMA, 299(16): 1914-21. [Abstract] [Full-text]
84. Correlates and outcomes of tumor adherence in resected colonic and rectal cancers.
    Ann Surg, 247(4): 650-8. [Abstract] [Full-text]
85. Can we predict immediate outcome after laparoscopic rectal surgery? Multivariate analysis of clinical, anatomic, and pathologic features after 3-dimensional reconstruction of the pelvic anatomy.
    Ann Surg, 247(4): 642-9. [Abstract] [Full-text]
86. Adequate preoperative staging rarely leads to a change of intraoperative strategy in patients undergoing surgery for colorectal cancer liver metastases.
    Surgery, 143(5): 648-57. [Abstract] [Full-text]
87. Alcohol drinking, cigarette smoking, and risk of colorectal adenomatous and hyperplastic polyps.
    Am J Epidemiol, 167(9): 1050-8. [Abstract] [Full-text]
88. Obesity and screening for breast, cervical, and colorectal cancer in women: a review.
    Cancer, 112(9): 1892-904. [Abstract] [Full-text]
89. Systemic therapy for metastatic colorectal cancer: current questions.
    Cancer, 112(9): 1879-91. [Abstract] [Full-text]
90. Prognostic and predictive factors in colorectal cancer.
    J Clin Pathol, 61(5): 561-9. [Abstract] [Full-text]
91. UGT1A1*28 polymorphism predicts irinotecan-induced severe toxicities without affecting treatment outcome and survival in patients with metastatic colorectal carcinoma.
    Cancer, 112(9): 1932-40. [Abstract] [Full-text]
92. Compound heterozygosity for two MSH6 mutations in a patient with early onset colorectal cancer, vitiligo and systemic lupus erythematosus.
    Am J Med Genet A, 146(10): 1314-9. [Abstract] [Full-text]
93. A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
    Nat Genet, 40(5): 623-30. [Abstract] [Full-text]
94. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.
    Nat Genet, 40(5): 600-8. [Abstract] [Full-text]
95. Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
    Nat Genet, 40(5): 631-7. [Abstract] [Full-text]
96. Potential regional differences for the tolerability profiles of fluoropyrimidines.
    J Clin Oncol, 26(13): 2118-23. [Abstract] [Full-text]
97. Individual fluorouracil dose adjustment based on pharmacokinetic follow-up compared with conventional dosage: results of a multicenter randomized trial of patients with metastatic colorectal cancer.
    J Clin Oncol, 26(13): 2099-105. [Abstract] [Full-text]
98. Pulmonary fibrosis after chemotherapy with oxaliplatin and 5-fluorouracil for colorectal cancer.
    Oncology, 73(3): 270-2. [Abstract] [Full-text]
99. Altered gene expression in rat colonic adenocarcinomas induced in an azoxymethane plus 2-amino-1-methyl-6-phenylimidazo[4,5-b]- pyridine initiation-promotion model.
    Oncology, 73(3): 252-60. [Abstract] [Full-text]
100. Prognostic implications of the distribution of lymph node metastases in rectal cancer after neoadjuvant chemoradiotherapy.
     J Clin Oncol, 26(13): 2106-11. [Abstract] [Full-text]
101. The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer.
     Int J Cancer, 123(1): 14-21. [Abstract] [Full-text]
102. Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras.
     Int J Cancer, 123(1): 100-7. [Abstract] [Full-text]

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